The amino acid L-arginine
is considered the most potent Nutraceutical ever discovered,
due to its powerful healing
properties, and is referred to by scientists as the Miracle
Molecule.
The remarkable properties of
L-arginine were validated by the 1998 Nobel Prize in Medicine,
and since then have created a frenzy of interest in the
Pharmaceutical and Nutraceutical fields.
Medical researchers
have gathered enough clinical evidence to bring L-arginine to the
forefront
of modern medicine as an
accepted treatment for a variety of human ailments. The L-arginine
phenomen is changing
standard treatment methodologies in heart disease, immune function,
adiposity-generated
diseases, genetic growth deficiencies, high blood pressure, sexual
disfunction, and human
aging.
BENEFITS
& FUNCTIONS
The efficacy of L-arginine
as a therapeutic agent has been validated by thousands of clinical
studies.
The benefits and functions attributed to oral ingestion of L-arginine
include:
• Precursor for the synthesis of Nitric Oxide (NO)
• Stimulation of the release of the most important anti-aging
hormone in the body, growth hormone.
• Improves immune function
• Reduces healing time of injuries (particularly bone)
• Reduces risk of heart disease
• Natural Alternative to Viagra
• Increases muscle mass
• Reduces adipose tissue body fat
• Helps improve insulin sensitivity
• Helps decrease blood pressure
• Alleviates male infertility, improving sperm production and
motility
Dosage
A typical dosage of arginine is 2 to 3 g of arginine per day.
In clinical trials, it is used in dosages
of 5 to 15 g for congestive heart failure.
The L- arginine possibly
strengthens the immunity function,
eveneffectively treats
certain cancers
Natural cures the master to
recommend the L- arginine to have the problem for the
function the male, in
particular these erections not long person. The L- arginine
may promote the blood to flow
to the
penis, then causes it to be
stronger. But the effect is short,therefore if uses its enhancement
performance, must in
front of the sexual intercourse the minute takes. Each people all
thought by no means it
is effective, but declared the L- arginine effect mysterious
masculine quantity are
many makes us not to dare to neglect it. Many research even
pointed out that, the L-
arginine may increase the spermatozoon number, therefore
possibly brings treats the
masculine sterility.
The L- arginine most becomes
famous place the stimulin manufacture;But the growth
hormone cancellation
eliminates the fat, molds the muscle extremely to be of help,
therefore the healthy
body often use she L- arginine to grow the muscle and gets rid .
In addition,the L- arginine
also has the important medical use, for example, after
the hospital is commonly used
the patient as well as the serious burn patient's wound
which it helps the surgery
recovers.
Figure 1 Metabolic
fates of arginine in mammalian cells
The five enzymes on which the central limbs of
the pathways are based include (clockwise from the top): nitric
oxide synthase (NOS), arginine:glycine amidinotransferase, arginase,
arginine decarboxylase and arginyl-tRNA synthetase.
Figure 2 Pathways of
arginine synthesis
Enzymes that catalyse the indicated reactions
are: 1, phosphate-dependent glutaminase
(EC 3.5.1.2); 2 and 3, P5C synthetase (EC number
not assigned); 5, ornithine aminotransferase
(OAT; EC 2.6.1.13); 6, ornithine
carbamoyltransferase (OCT; EC 2.1.3.3); 7
, argininosuccinate synthase (ASS; EC 6.3.4.5);
8, argininosuccinate lyase
(ASL; EC 4.3.2.1); 9, N-acetylglutamate
synthase (EC 2.3.1.1); 10,
carbamoyl-phosphate synthase I (ammonia)
(CPS I; EC 6.3.4.16); 11,
proline oxidase (EC number not assigned); 12,
aspartate aminotransferase
(EC 2.6.1.1). Step 4 is a spontaneous, non-enzymic
reaction.
Glutamyl-g-semialdehyde is in chemical
equilibrium with P5C. The chemical equilibrium
favours P5C formation [21,22]. P5C
synthetase is a bifunctional polypeptide that exhibits
both g-glutamyl kinase (glutamate 5-kinase; EC
2.7.2.11) and g-glutamylphosphate reductase
(glutamate-5-semialdehyde dehydrogenase; EC
1.2.1.41) activities
(reactions 2 and 3 respectively) [41].
Reactions 1–6 and 9–11 occur in mitochondria,
reactions 7 and 8 take place in
the cytosol, and reaction 12 can occur in
both mitochondria and the
cytosol. Abbreviations: OAA, oxaloacetate;
CP, carbamoyl phosphate.
Figure 6 Developmental changes in arginine catabolism by pig
enterocytes
Enterocytes were
isolated from the jejenum of pigs at various times after birth (day
0) and incubated in Krebs Bicarbonate buffer containing 5 mM
D-glucose and
2 mM arginine. Pigs were weaned at day 21. Data are from Table 3 of
Wu [217].
|
Flux/supply/synthesis (µmol/h per kg body wt.) |
|
|
Plasma
concn. (µM) |
|
|
|
Exogenous
supply |
Endogenous
flux |
Endogenous
synthesis |
|
|
|
|
Animals or
humans |
Nutritional
state |
Citrulline |
Arginine |
Flux of
plasma Arg |
of Arg to
circulation |
of Arg |
of Arg from
Cit |
|
Human infant1 |
TPN |
11 |
115 |
125 |
29 |
96 |
?? |
|
Human infant2 |
TPN |
?? |
?? |
209 |
69 |
140 |
15 |
|
Adult human3 |
Enteral |
27 |
210 |
73 |
22 |
51 |
5.2 |
|
Neonatal pig4 |
Enteral |
89 |
163 |
408 |
93 |
315 |
96 |
|
Growing pig5 |
Enteral |
64 |
159 |
319 |
65 |
254 |
65 |
|
Adult rat6 |
Enteral |
62 |
175 |
479 |
55 |
424 |
65 |
|
Adult dog7 |
Post-absorptive |
31 |
178 |
225 |
0 |
204 |
9.4 |
Virtually all flux of plasma
citrulline is associated with endogenous synthesis of arginine in
adult humans [62]
and rats , but apparently not in adult dogs . Endogenous synthesis
of arginine from citrulline is not responsive to reduced dietary
intake of arginine in adult rats or humans .
IN HEALTHY
Arginine has several important functions. It is
essential to the metabolism of ammonia that is generated from
protein breakdown. It is also needed to transport the nitrogen used
in muscle metabolism.
Arginine is one of the body-building amino acids and also influences
several hormone functions. L-arginine has been shown to stimulate
the pituitary gland to produce and secrete human growth hormone in
young males, at a dose of more than 3 grams daily.
IN
SKIN CARE
The arginine refinement is pure naturally puts on
make-up the water,drop pure, easily by flesh absorption. The anti-
wrinkle, delays senilly, the promotion growth hormone secretion,
enhances the immunity function, Causes the flesh health maintenance,
tightly sends has the elasticity
Rough, appears the wrinkle the flesh to attain
the elasticity again, reduces the wrinkle, the arginine and the skin
physiology mutually cooperates, promotes the skin to be tender young
slides, slows down
senilly, has the special affinity to the skin,
may give the skin directly to guarantee the wet effect
How
to use?
Even on now and front
directly spreads wipes to the face, after treats completely absorbs
defers to the general maintenance step again.
