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 超氧歧化脢.SOD
Super oxide Dismutase
1.The super oxide Qi turns the brief name SOD, is the abbreviation
of English Superoxide Dismutase, is a body inside resist a free
radicals together defense line, be our body inhale the oxygen carry
on metabolism will produce the super oxygen anion(O2-) free
radicals, if don't give cancellation and will produce chain reaction
in the body, break our cell, is the human body is aging and the
cause of the disease, happily there is SOD in the body remove
them.The SOD is in only function inside the body is remove super
oxygen ion, make them become to have no to the human.
2. SODs is a kind of enzymes.The healthy person can make 5,000,000
SOD and its colleague of the units to lead to oxidize hydrogen (catalase)nearly
everyday#.The SOD also helps body to make use of zinc, copper,
manganese.Increase gradually along with the age, the SOD density
will reduce, the content of the free radicals increases at this
time.It is studied just currently.The SOD complement article of the
tablet or the medicine slice has to be had one film, making SOD
ability the integrity didn't lack ground to arrive the small
intestines absorbability through the stomach department.Add an
article and have to can provide about 5,000,000 or higher unit of
the day need quantity.The natural SOD sees in the barley grass,
green cauliflower, cabbage vegetables bud, cabbage, wheat grass, and
greatly part of green plants.
SOD function mechanism
3.The human body metabolism will produce a kind of outcome with
greatly vice- activity to call "the reaction oxygen clan".(ROS, the
reactive oxygen species, call ROS as follows)The ROS will hurt the
cell, organization and DNA.More and more evidence shows the ROS is
also necessary to life.If the ROS is super to oxidize an anion(the
superoxide anion), is the weapon that the leukocyte deals with the
cause body;Then have something to do with blood pressure adjusting
to control while oxidizing nitrogen(the nitric oxide).ROS even
possible the oneself adjust to control the metabolism rate, many
genes and protein are thought to resist to oxidize to press and
prolong life, leading to oxidize hydrogen#(catalase)turn(the
superoxide dismutase) with the super oxygen thing Qi-handle of
nematode, can compare normally of live 44%(the Bick Institute Simm
Melov detection) more in the fruit fly, some extension life of the
mutation can increase the power that the anti- oxidizes to press in
the meantime.For example the fruit fly of[with] the methuselah gene
mutation, live not only longer, and all have holdout to the heat and
the insecticide"paraquat"(destroy insects by increasing a great deal
of ROS)ses.
● The substantial evidence of individual disease and the anti- free
radicals medicine treatment
1.The myocardial lacks blood:
The Vladimilov reported the artery gruel kind to harden the
sufferer's fat inside the blood plasma to lead the oxide(LPO)
content to go up in 1986.LPO's going up is the blood oxygen free
radicals function in the result of the fat, becoming the vicious
cycle of the coronary outbreak, and the myocardial lacks the example
that the blood is a typical model.Have already known the free
radicals participates a myocardial to lack the again infusing of the
blood Zhu harm evidence to have currently:(1)The fat leads to
oxidize the outcome C two Quans increment;(2)Anti- inside the
organization oxidizes#the activity descend, oxidizing to hurt to
oxidize with anti- to be out of balance.(electron spinresonance;
ESR)its application, free radicals after all obtaining to infuse
again Zhu in great quantities born direct evidence. When myocardial
lacked blood to infuse again Zhu, the creation of the free radicals
contain three important paths.(1)While lacking blood to infuse again
Zhu, swiming to leave calcium can activate the Lin fat, can make the
cell membrane Lin fat decline a solution, releasing peanut four Xis
sour, the latter can accelerate the free radicals formation of the
wreath oxygen and the fat oxygen catalyst.(2)Lacking the blood can
trigger to repair the body system to activate and tend a creation of
turning the factor, both all can cause to lack blood to infuse again
to love a neutral grain cell to pile up in the Zhu area, can oxidize
creation free radicals through a NADPH.(3)Lack blood the oxygen
provide quick decrease, urging to lack the blood area ATP to resolve
for the yellow Biao purine to accumulate to gather continuously, in
the meantime grain the gland body function is damaged, the cell dye
that breathes a chain eventually an end oxidizes(the cytochrome
oxidase) is repressed, cause the yellow Biao purine take off
hydrogen(the xanthine dehydrogenase) to develop to oxidize for the
yellow Biao purine, in the process the formation of the super oxygen
free radicals.According to move.
2.The mental exertion crocks up
Heart because the pressure burden and capacity carries a surfeit,
final often can cause the mental exertion crock up.Relevant free
radicals, all haded affirmation at home and abroad ago together of
clinical research paper.Hint the heart Shuai exist an obvious fat
over oxidize respond to strengthen, the anti- oxidizes#the ability
reduce.For example, someone to strenuous effort patient and normal
person's 100 for each, after investigating the SOD of the red
corpuscle point out its result as the former only 76.28+ is 20.79 μ
g/mls.And then 107.22+ then is 29.03 μ g/mls.The medicine that cured
cardiovascular disease few days ago maximum amount, but some
curative effect is very low, using the SOD concert reatment can make
result more obvious.
3.Shock:
To the research of the shock.was laid particular emphasis on in low
blood pressure quantity, cardiovascular dynamics and lost the liquid
therapy in early days etc., in the shock of various type.the
creation of the oxygen free radicals was the Zong color result of
the much heavy factor:
(1)Organize to re- acquire rich oxygen blood to infuse Zhu after the
shock appearance turn for the better, organize to take off hydrogen
in the yellow Biao purine at this time#conversion oxidize for the
yellow Biao purine#, is declined solution by the ATP to become
yellow Biao of yellow Biao purine, time to sing to metabolize
further in the catalyst the organization, release a great deal of
O2-.
(2)Wound ache, lose blood, cold incitement and should arouse
reaction causing it, the body can release a great deal of son tea
Fen An, at adrenaline from oxidize and the body re- synthesize
adrenaline all can release O2-.
(3)In addition to the endotoxin shock is starting a stage and then
stimulating a grain cell to activate to release O2 with it-, the
other,such as the wound shock appearance, "infection"s to all become
an outstanding problem in slightly and late some time, at this time
organize inside a great deal of cell gradually and release a great
deal of O2-. In the shock appearance particularly is the shock that
merges to infect, the live oxygen free radicals rose to emphasize to
want to use yesterday in the organization the damage and the shock
the outbreak the mechanism, therefore, at the shock took place,
needed an anti- to oxidize the Mei or anti- oxidizing agent help
rather.
4.Many system organs crock up:
Many system organs crocking up(the multiple system organ
failure;MSOF) is more a clinical symptoms that is valued more, and
the recent years free radicals cause the detection of the
organization harm, for studied the MSOF mechanism to provide
important clues.By organize the organ part to lack the blood or the
Yan disease and cause oneself of the free radicals hurt of fact,
already confirm extensively;The harm of the liver, lung usually more
outstanding, its reason has at least in great quantities huge bite
cell and can become abundant free radicals source after activating
relevant.Was proven by the corpse check data, the MSOF pathologic
change takes the non- particularity Yan disease as its
characteristic, this important position that proves a free radicals
further in the MSOF the outbreak the mechanism, the damage of the
definite free radicals is a blood vessel first inside skin of
damage, cause afferent transparence increment and organize edema
etc. the Yan disease respond.Therefore.give in the possible scope
the anti- oxidize therapy to still belong to a necessity.
5.The adult breathes hard-pressed symptoms:
The adult breathes hard-pressed symptoms(the adult respiratory
distress syndrome;ARDS) and calls impatient lung harm.for the shock,
wound, burn, infect, inhale a kind of complications of special type
of poisonous air etc. severity disease, is one of the important
cause of diseases that the Wei heavy disease causes death. Many
facts all think that the ARDS lung harm is come together with lung
of with by repairs the neutral grain cell that the body activates to
release of the oxygen free radicals etc. toxic material
relevant.When the impatient lung hurt, in great quantities neutral
grain after activating the cell be detained by the lung, releasing a
great deal of O2 while being "breath explosion"-, and the SOD and
CAT etc. anti- oxidize#reduce, the H2 O2 cans not gets in time of
clearance, their interaction becomes the high and live oxygen
metabolism thing to cause the lung organization harm.The oxygen free
radicals has a direct toxicity function not only to the lung
organization, and passes a neutral grain cell to tend to turn factor
of born, can also enlarge the Yan disease to respond, aggravate the
organization harm that waits for to the lung.In case of meet such of
the patient match with usage anti- to oxidize therapy and will do
good greatly for sufferer to saying.
6.The self immunity disease and anti- Yan function:
As for the self immunity disease medical science field there are
very a few parlances, in recent years again someone think because
the some link mechanism for cell to oxidizes metabolism is out of
tune, causing the SOD content reduce and O2-with the other oxygen
free radicals density increment with the result that.Someone tries
out SOD treatment rheumatism arthritis, whole body erythema lupus,
the gram Long surname disease(the Crohn's disease)...etc., through
after curing a few months obtained obvious result;But also the one
who have to hold a negative attitude.Say aught, cure a chronic
rheumatism arthritis(a muscle Zhu 8 mgs, every week 2-4 times), the
bone arthritis(inject a 4 mgs once toward the joint Qiang, inject
every two weeks) with Er fruit Ting in above Europe, and more than
100 prostate gland cancers or the urine bladder cancer project the
linger effect"the radio bladder inflammation" of curing the back(a
muscle inject a 4 mgs, the total measures a 8-70 mgs;The best is in
the treatment the back the half an hour to inject immediately for
good)etc., all obtained good result.Didn't hurt to the cartilage
organization in the anti- Yan process, also have no side effect,
better than steroid and non- types solid medicine.
7.With other several relation for getting sicks:
Someone measuresed 33 kidney diseases to wait a flock to suffer from
son and 32 health child the oxygen free radicals and concerning
clinical index sign, find as a result:
1.While waiting a group of childs with the healthy child and the
kidney disease to alleviate to expect to compare, in the kidney
disease wait a flock of impatient period that suffers from son, the
total and super oxide Qi of the blood plasma turns#(TSOD), the CuZn-SOD,
the GSH-Px activity is obvious to reduce, the MDA content rises;In
the high urine TSOD, CuZn-SOD, the GSH-Px is live to build up, and
the MDA content have no obvious change.
2.The related analysis hints, the blood plasma TSOD and white egg
white present just related;The blood plasma MDA and white egg white
present to take related, with urine the amount of egg white present
just related;Urining the TSOD and urine egg white fixed amount
presents just related.Besides, 17 beginnings cure to suffer from son
from usage the steroid go to urine egg white to disappear time and
its acute needed to expect the blood plasma MDA to present just
related and TSOD negative related, and present and TSOD/MDA height
negative related.This research hints, the kidney disease waits a
flock to suffer from the son body inside exist an anti- to oxidize
an ability to reduce to lead to oxidize to build up, its degree and
clinical processes with fat closely related.The body will produce
the free radicals of a series after ising subjected to emanation
line project light upon, among them to human body endanger biggest
is O2-with OH, and can cause radiation behind synthesize condition
of illness, severity can cause death.
Someone does to experiment with the small white rat, at before
radiating or radiation after use the certain SOD for measuring, can
reduce emanation line consumedly to the harm of the machine body
cell, reduce linger effect;Don't add to use the SOD its survival
before projecting the line irradiation.
8.The oxygen free radicals and decrepitude:
The free radicals oxidizes the living creature numerator, is one of
the important mechanisms of the decrepitude occurrence.Aging
hour"fat brown quality"(lipofuscin;Call old-age dye again)pour is a
more important marking;On the other hand because of fat of over
oxide and the structure and function of the breakage cell, make on
the other hand big numerator of living creature of the occurrence
hand over Lian, coming together the huge numerator of the
abnormality, piling up in dissolve the body, becoming a kind of
sloth discard of cancellation with hard cell ……fat brown quality.
Experiment according to the animal, the cell centerline grain the Mn-SOD
activity in the body, 20 months of big rat ratio in August age the
big rat is obvious to descend, and the male severity in
pantheress.The recent years also had many scholars to carry on
investigating to the mankind, though some data has a little bit
discrepancy up, the total trend is the SOD value along with increase
an age and descend.For example:Someone's measuresed youth a person's
red corpuscle SOD content is(the μ g/g.Hb) 481.43 ±s 10.13, and the
old people are then for421.24±27.17(P<0.01)。And then someone to
youth(18-33 years old), the old age expected(50-59 years old) ago,
longevity old age(90-96 years old) etc. a few blood MDAs, the SOD
content carried on a measurement, along with the increment of the
age, the content of the SOD is reducing continuously, the content of
the MDA increased continuously.
More someone's data shows:The healthy person red corpuscle SOD is
worth, the 20-29 years old set is obvious and low in child's
team;Later 30-59 years old of each 10 years old set the degree with
gradually light value descend, but set have no obvious
difference;60-99 years old of each 10 years old set the value have
no obvious rise and fall;The 100-108 years old set has already
reduced trend slightly.Among them, the middle age expects to add up
a set of SOD to be worth to compare adolescence aggregate a set a
value to is to be obvious to reduce;But win an old-age set the , old
age and the longevity set, the SOD is worth to then have no obvious
difference.Therefore increase the outside source SOD and other anti-
oxidizing agents, and the hour clearance excessive oxygen free
radicals, possibility availably anti- decrepitude(anti-aging).
9.Care food SOD
Breathing air everyday is for needing oxygen to make the organ
circulate, be us to attract oxygen, the oxygen will be entered blood
by the lung, is been afferent by the heart to send the oxygen to the
body each place, carry on various reaction.But the oxygen will
produce the oxygen free radicals in the function process, the oxygen
free radicals will have to the cell of the human body to kill wound
power very greatly, will make diseases, such as gene mutation and
arteriosclerosis...etc., there is the nature defense system-SOD in
the body can will super oxidize a free radicals to clean.The SOD is
a kind of anti- oxidizing agent, the natural food that contains SOD
comes from green plant almost and all, as barley bud grass, wheat
bud grass, Cruciferae vegetable etc..If make into the nourishment
complement tablet then want to plus the protection layer in order to
prevent is lost result by the stomach acid decomposition in its
stomach, and ability directly since the childhood the bowel
absorbability make use of.So the taking of adequacy anti- oxidizing
agent and related nourishment complement article to maintain,
prevent cancer, anti- is beneficial always and rather.
●Conclusion
The some anti- free radicals medicine has of already applied in
clinic, as the vitamin E, C, AN etc. have abundant of experience,
extends it to apply to prevent and cure in the Wei disease, develop
the function that its anti- oxidizes harm, this may has no a problem
to clinical doctors.The problem is all an any functions of medicine
to have it to limit sex, adding it to oxidize to hurt and ising a
complicated process, this need how choose a few functions of
different medicine, reach larger curative effect.
Value the research of the anti- free radicals medicine and develop
more and more at home and abroad currently, in addition to hard
extension the scope of the new species is outside, to the anti- free
radicals medicine that have already affirmed as:The SOD, the vitamin
E etc. is improving in the Gou effect to reduce its weakness and
increase particularity.As SOD because the half- life is very short
and the obsolescent clinical application, the recent years applies
to gather ethylene two Chuns the super oxide Qi turn enzyme half-
life and can reach to for 30 hours, and can stick to attaching in
the skin surface inside the blood vessel, increasing its nti- free
radicals function;The SOD that produces with the genetic
engineering's gathering body more will also be applied in a
clinic.Worthy of particularly put forward of BE, the some Wei heavy
disease person's pathology is very complicated, the possible nerve,
endocrine, nourishment metabolism, immunity and various body fluid
factors all participate among them, be in a certain situation and a
certain degree top free radicals likely to be unique with the result
that hurt material, in order to correct the whole process of
disease, anti- free radicals have to also and other medicine and
prevent and cure of all possible measure unites an application in
the meantime, can acquire more ideal curative effect.
Really there is obvious result in the SOD anti- skin the aging
function experiment and reduce the function of the melanin
content.The SOD is a rather popular anti- to oxidize a product now,
its reason BE, the live oxygen(the Active Oxygen) of one of no
matter inside or foreign factor and free radicals inside the body
of[with] creation has already caused the cell membrane and the cell
fat lead oxidize of function, as a result broke the normal growth of
the cell, cause aging and other problems.Therefore wait for a
natural anti- to oxidize composition to become modern cosmetics to
spoil son toward the SOD.Much skin care products increases SOD,
being the product protection on the other hand, reaching an aging
purpose of the skin anti- on the other hand.Besides, if the skin
contain the small wound of the shallow layer, the suggestion can use
SOD an original liquid to help the wound Yu to match and repair and
maintenance.
The appearance of the thin Wen, the initial stage may is because of
what the skin aridity causes, as long as does like hydrate and can
immediately improve, but if long-last accumulation of injury, still
probably appear true of veins is a particularly modern female due to
insolation, pollute, pressure, live falsely often, sit up, smoke
etc., all may make the false of the skin aging in advance, make the
skin age present more than 30 years old Ans, flabby, thin Wen etc.,
therefore resist aging, really is in spite of age, prevent aging
want early as possible.
To the 30-year-old female for do not say, suggest that do old
preparation of good anti- everyday, use some anti-s to oxidize
particularly and much, the composition of the anti- free radicals,
as the SOD anti- mature and steady cent, and really do to like to
defend to insolate with hydration, then prevention aging of appear
in advance.
Young female ignore from how old start maintaining, all want to
build up a right idea BE:Protect.
Oxidize to respond is a kind of chemical reaction what to point,
having to certainly coming in contact with oxygen not then would
take place, skin inside most main of oxidize reaction excessively,
mainly by each kind of free radicals cause.Ultraviolet ray, project
line, smoke to drink, the exercise excessiveness, nervous pressure,
edible the excessive processed food, sugar and grease, will make
free radicals a great deal of creation, accelerate cell to oxidize.
When the unsteady free radicals produces after, will start attacking
normal numerator, cause reaction of producing the catena, bring much
injury to the living creature cell, include to cause the cell
membrane unsaturated fatty acid sour of over oxidize, then change
the transparence of the cell membrane, or because of acceleration
DNA inside the cell oxidize injury, causing the gene mutate, then
making skin aging lightly, the skin presents of omen,such as crease,
spot, pimple...etc., , heavy then cause body of the immunity power
reduce, heart afferent disease, high blood pressure, glycouria the
far-gone chronic disease finds to come slowly.
Even can reduce various foreign free radicals injury as far as
possible, the living creature body as long as breathe the function,
energy conversion to keep on carrying on, body inside will also have
the free radicals creation for diverting continuously, can't avoid
completely.The anti- that have to depend on the human body formation
at this time oxidizes enzyme(SOD, GSH etc.) and contiguously
complementary each kind of anti- to oxidize composition, resist a
free radicals;Aims at the small injury that the free radicals causes
in the meantime, also want to take in to repair to pile up by
reducing injury at any time.Wanting to synthesize an anti- to
oxidize enzyme and keeping on repair cell has to need depend on a
great deal of amino acids, therefore, the adequacy takes the
protein, vitamin and anti- to oxidize a food very important, and use
anti- more to oxidize to protect skin care products.Want to avoid
ultraviolet ray, smoke harm, getting empty as far as possible in
addition.
The anti- oxidizes, what to represent is the prevention is
aging.Ignore any age, any skin quality, all is threatenned by the
aging injury at any time, all need to put on the protection cover
for the skin, from this, the anti- oxidizes composition, are all
helpful to anyones.Just, real young and healthy skin, the metabolism
is prosperous, making repair function stronger, is hurt by the free
radicals even if, can also repair very fast, hurt a not easy
accumulation, so, oxidize to maintain in the anti- up, relatively
will not emphasize its importance excessively. But no matter men and
women, go to 25 years old above, because the metabolism starts
becoming slowly, and the pollution of the environment, ultraviolet
ray, smoke harm, live pressure etc. unavoidable, once the quantity
of the free radicals inside the body have another get up, body
inside repress the SOD of the free radicals and can not produce
result, the free radicals will start breaking our cell then;If hurt
accumulation of speed exceed the repair speed of the skin, will
present in the appearance then, let the skin lose the flexibility
and sheen, cause various outside and aging phenomenon of creation,
therefore strengthens the protection that the anti- oxidizes, can
keep skin from the injury pile up with advance aging occurrence.
Need ethnicity:
1. Arthritis and autoimmune disease sufferer
2. Traffic accident, sprain and wound sufferer
3. High uric acid, gout, shoot to protect swelling of gland greatly,
liver disease sufferer
4. Cancer, heart attack, glycouria far-gone chronic disease sufferer
5. Drink, take out the cigarette habit
6. The modern people, middle age and old people cares generally
7. The immunity ability shortage
8. The blood fat leads high, heart afferent disease
9. Chronic disease, cancer dangerous flock
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